Jakarta, Kompas - Physical activity in the form of sports, daily activities and even dancing are done routinely useful to prevent atherosclerosis (fatty deposits on artery walls). This was proven by autopsy seven-time Boston marathon champion, Clarence DeMar, which indicates the size of coronary arteries from two to three times its normal size and did not reveal any stenosis (narrowing of blood vessels) are significant despite the age of 69 years died.
Relation of physical activity with coronary heart disease prevention due to atherosclerosis is discussed Dr. Dr. Dede Kusmana SpJP (K) (60), in a speech at the inaugural ceremony as Professor of Cardiology at Stay in the Science Faculty of Medicine, University of Indonesia, Wednesday (18/6).
According to Dede who is also Chairman of the Section of Cardiology Faculty of medicine, especially aerobic physical activity increases blood flow which is a wave that encourage increased production of nitric oxide (NO) and stimulate the formation and release of endothelial relaxing Derive factor (EDRF), which relax and dilate blood vessels.
Coronary blood flow during rest approximately 200 ml per minute (four per cent of the total cardiac output). Lab studies show, increase blood flow 4 ml per minute was able to produce NO to stimulate the improvement of endothelial function (lining) of blood vessels.
"Therefore, being in the form of physical activity or walking exercise that increases blood flow to 350 ml per minute (up by 150 ml per minute) was more than enough to avoid the vascular endothelium of the atherosclerotic process," says Dede.
However, the benefits can only be obtained if the increase in blood flow through regular physical activity takes place in a long time (20 minutes to an hour), and performed regularly for life.
Mechanism of atherosclerosis
Dede explains that atherosclerosis begins with buildup of cholesterol, especially LDL-cholesterol ester (low density lipoprotein) in the arterial wall. LDL normally get in and out of the artery through the endothelial wall. The entry of lipoproteins into the inner lining of the blood vessel wall increases with the high number of lipoproteins in plasma (hyperlipidemia), the size of the lipoprotein and blood pressure (hypertension). Increase in all it will increase the permeability of the blood vessel walls, thereby precipitated lipoproteins and cholesterol esters in the arterial wall.
Malfunctioning of the blood vessel lining became the beginning of the process of atherosclerosis and inflammatory mechanisms and encourage infection.
Inflammation or inflammation is the body's basic response to injury (injuries). Injuries are usually caused by infection, but can also be allergic or immunological reaction.
Clinical manifestations of the complex process of atherosclerosis is coronary heart disease, stroke and even death.
According to the Framingham study, as Dede, C-reactive protein (CRP) is a sign (marker) inflammation associated with cardiovascular events and stroke.
Efforts to suppress inflammatory factors may prevent the atherosclerotic process. Regular physical activity is proven to suppress CRP, mean also suppress inflammatory factors.
Therefore, moving or doing regular physical activity is an early concept of cardiovascular disease prevention and rational efforts for patients with cardiovascular disorders in cardiac rehabilitation.
Resistance training combined with weight training for four months been shown to decrease levels of TNF alpha (a type of inflammatory cytokines) were significantly reduced in patients with heart failure and coronary heart disease.
Type of activity
In healthy people, the prevalence of hypertension, hyperlipidemia, and ischemia (blood deficiency conditions in the network) is lower in people with more severe physical activity and regular than irregular or no exercise.
May be concluded, regular physical activity have the protection against cardiovascular mortality as well as other diseases due to lifestyle (non communicable disease).
No need to exercise a difficult and expensive. Walking six miles per hour, aerobics weight is, dancing is adequate to maintain cardiovascular health. Similarly, the equivalent of activities such as climbing stairs two levels, carrying 10 kilograms, hoe, or gardening.
"Activities of any origin can increase heart rate between 110-130 per minute, accompanied by sweating and increased respiratory rate but not until the panting is good enough to prevent heart disease and stroke," explained Dede. (ATK)
Relation of physical activity with coronary heart disease prevention due to atherosclerosis is discussed Dr. Dr. Dede Kusmana SpJP (K) (60), in a speech at the inaugural ceremony as Professor of Cardiology at Stay in the Science Faculty of Medicine, University of Indonesia, Wednesday (18/6).
According to Dede who is also Chairman of the Section of Cardiology Faculty of medicine, especially aerobic physical activity increases blood flow which is a wave that encourage increased production of nitric oxide (NO) and stimulate the formation and release of endothelial relaxing Derive factor (EDRF), which relax and dilate blood vessels.
Coronary blood flow during rest approximately 200 ml per minute (four per cent of the total cardiac output). Lab studies show, increase blood flow 4 ml per minute was able to produce NO to stimulate the improvement of endothelial function (lining) of blood vessels.
"Therefore, being in the form of physical activity or walking exercise that increases blood flow to 350 ml per minute (up by 150 ml per minute) was more than enough to avoid the vascular endothelium of the atherosclerotic process," says Dede.
However, the benefits can only be obtained if the increase in blood flow through regular physical activity takes place in a long time (20 minutes to an hour), and performed regularly for life.
Mechanism of atherosclerosis
Dede explains that atherosclerosis begins with buildup of cholesterol, especially LDL-cholesterol ester (low density lipoprotein) in the arterial wall. LDL normally get in and out of the artery through the endothelial wall. The entry of lipoproteins into the inner lining of the blood vessel wall increases with the high number of lipoproteins in plasma (hyperlipidemia), the size of the lipoprotein and blood pressure (hypertension). Increase in all it will increase the permeability of the blood vessel walls, thereby precipitated lipoproteins and cholesterol esters in the arterial wall.
Malfunctioning of the blood vessel lining became the beginning of the process of atherosclerosis and inflammatory mechanisms and encourage infection.
Inflammation or inflammation is the body's basic response to injury (injuries). Injuries are usually caused by infection, but can also be allergic or immunological reaction.
Clinical manifestations of the complex process of atherosclerosis is coronary heart disease, stroke and even death.
According to the Framingham study, as Dede, C-reactive protein (CRP) is a sign (marker) inflammation associated with cardiovascular events and stroke.
Efforts to suppress inflammatory factors may prevent the atherosclerotic process. Regular physical activity is proven to suppress CRP, mean also suppress inflammatory factors.
Therefore, moving or doing regular physical activity is an early concept of cardiovascular disease prevention and rational efforts for patients with cardiovascular disorders in cardiac rehabilitation.
Resistance training combined with weight training for four months been shown to decrease levels of TNF alpha (a type of inflammatory cytokines) were significantly reduced in patients with heart failure and coronary heart disease.
Type of activity
In healthy people, the prevalence of hypertension, hyperlipidemia, and ischemia (blood deficiency conditions in the network) is lower in people with more severe physical activity and regular than irregular or no exercise.
May be concluded, regular physical activity have the protection against cardiovascular mortality as well as other diseases due to lifestyle (non communicable disease).
No need to exercise a difficult and expensive. Walking six miles per hour, aerobics weight is, dancing is adequate to maintain cardiovascular health. Similarly, the equivalent of activities such as climbing stairs two levels, carrying 10 kilograms, hoe, or gardening.
"Activities of any origin can increase heart rate between 110-130 per minute, accompanied by sweating and increased respiratory rate but not until the panting is good enough to prevent heart disease and stroke," explained Dede. (ATK)